Ingestibles are amazing. But, finding them once swallowed is hard. We used Wearables+Ingestibles+AI to create a wearable system that can locate ingestibles in the gut with millimeter resolution while measuring oxygen and ammonia gasses. Hats off to Angsagan Abdigazy, Mohammed Arfan, June Shao, Mohammad Shafiqul Islam, and Md Farhad Hassan for showcasing this beautiful work. 💊⚕️

Paper title: 3D gas mapping in the gut with AI-enabled ingestible and wearable electronics

Abstract: Gas measurements in the gastrointestinal (GI) tract aid in the diagnosis and continuous monitoring of disorders such as irritable bowel syndrome, inflammatory bowel disease, and food intolerances. Traditional methods for measuring and locating these gases are often invasive, typically requiring hospital-based procedures. Ingestible electronics provide a more convenient solution, yet locating these devices remains challenging. Here, we present a wearable platform that implements a magnetic-field-based 3D localization of ingestibles with millimeter-scale resolution: <2.2 mm with lookup-table-based and < 4.2 mm with neural-network-based algorithms, respectively. Our ingestible pill, equipped with optoelectronic gas sensors, can detect oxygen (O2) in 0%–20% and ammonia (NH3) in the 0–100 ppm concentration range. The NH3 measurements can serve as a proxy for identifying Helicobacter pylori, a bacterium linked to peptic ulcers, gastritis, and gastric cancers. Overall, this work aims to empower patients to conveniently assess their GI gas profiles from the comfort of home and manage digestive health.

Publication:

  1. 3D gas mapping in the gut with AI-enabled ingestible and wearable electronics Angsagan Abdigazy, Mohammed Arfan, June Shao, Mohammad Shafiqul Islam, Md Farhad Hassan, and Yasser Khan Cell Reports Physical Science, 2024

    Gas measurements in the gastrointestinal (GI) tract aid in the diagnosis and continuous monitoring of disorders such as irritable bowel syndrome, inflammatory bowel disease, and food intolerances. Traditional methods for measuring and locating these gases are often invasive, typically requiring hospital-based procedures. Ingestible electronics provide a more convenient solution, yet locating these devices remains challenging. Here, we present a wearable platform that implements a magnetic-field-based 3D localization of ingestibles with millimeter-scale resolution: <2.2 mm with lookup-table-based and <4.2 mm with neural-network-based algorithms, respectively. Our ingestible pill, equipped with optoelectronic gas sensors, can detect oxygen (O2) in 0%–20% and ammonia (NH3) in the 0–100 ppm concentration range. The NH3 measurements can serve as a proxy for identifying Helicobacter pylori, a bacterium linked to peptic ulcers, gastritis, and gastric cancers. Overall, this work aims to empower patients to conveniently assess their GI gas profiles from the comfort of home and manage digestive health.

    @article{abdigazy20243d, title = {3D gas mapping in the gut with AI-enabled ingestible and wearable electronics}, author = {Abdigazy, Angsagan and Arfan, Mohammed and Shao, June and Islam, Mohammad Shafiqul and Hassan, Md Farhad and Khan, Yasser}, journal = {Cell Reports Physical Science}, year = {2024}, publisher = {Cell Press}, doi = {10.1016/j.xcrp.2024.101990}, thumbnail = {abdigazy20243d.png}, url = {http://dx.doi.org/10.1016/j.xcrp.2024.101990}, pdf = {abdigazy20243d.pdf} }

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