Ansa's Paper on Ingestibles in IEEE BioCAS

Another cool paper at the end of the year. We have developed a single-chip chemical sensing ingestible that can self-orient. With this ingestible platform, the possibilities are limitless. Congratulations to all the authors: Angsagan Abdigazy, Shafiq Islam, Mohammed Arfan, Md Farhad Hassan, and Prof. Hossein Hashemi. 💊✨

Paper title: A Self-Orienting Single-Chip Ingestible Pill for Electrochemical Sensing in the GI Tract

Abstract: This paper presents a self-orienting ingestible pill that integrates a custom chip and an electrochemical pH sensor. The chip, fabricated using the TSMC 180nm CMOS process, integrates an analog front end (AFE) for 3-electrode electrochemical sensors, a closed-loop voltage-controlled oscillator (VCO)based analog-to-digital converter (ADC), a radio frequency (RF) transmitter (TX) with an off-chip loop antenna, clock and control logic, and a power management unit (PMU). The 1μ W, chopper-stabilized AFE can measure sensor currents in the ±29μ A range and achieves a minimum detectable current of 150 pA. The 1.2μ W, time-based ADC achieves a 9.6-bit ENOB with a 100ms conversion time. The TX operates in the 402−405MHz Medical Implant Communication System (MICS) band, utilizing either On-Off Keying (OOK) or Frequency Shift Keying (FSK) modulation, with an average power of as little as 32μ W. The chip and fabricated pH sensor are integrated onto a flexible polyimide printed circuit board (PCB) and encapsulated in a custom 3Dprinted self-orienting shell (∅6.2 mm×17 mm) that ensures the sensor consistently faces the gastrointestinal (GI) wall for more reliable measurements.

Publication:

1. 
   A Self-Orienting Single-Chip Ingestible Pill for Electrochemical Sensing in the GI Tract Angsagan Abdigazy, Mohammad Shafiqul Islam, Mohammed Arfan, Md Farhad Hassan, Hossein Hashemi, and Yasser Khan In 2024 IEEE Biomedical Circuits and Systems Conference (BioCAS), 2024 Abstract

   This paper presents a self-orienting ingestible pill that integrates a custom chip and an electrochemical pH sensor. The chip, fabricated using the TSMC 180nm CMOS process, integrates an analog front end (AFE) for 3-electrode electrochemical sensors, a closed-loop voltage-controlled oscillator (VCO)based analog-to-digital converter (ADC), a radio frequency (RF) transmitter (TX) with an off-chip loop antenna, clock and control logic, and a power management unit (PMU). The 1μ W, chopper-stabilized AFE can measure sensor currents in the ±29μ A range and achieves a minimum detectable current of 150 pA. The 1.2μ W, time-based ADC achieves a 9.6-bit ENOB with a 100ms conversion time. The TX operates in the 402−405MHz Medical Implant Communication System (MICS) band, utilizing either On-Off Keying (OOK) or Frequency Shift Keying (FSK) modulation, with an average power of as little as 32μ W. The chip and fabricated pH sensor are integrated onto a flexible polyimide printed circuit board (PCB) and encapsulated in a custom 3Dprinted self-orienting shell (∅6.2 mm×17 mm) that ensures the sensor consistently faces the gastrointestinal (GI) wall for more reliable measurements.

   Bibtex

   @inproceedings{abdigazy2024self, title = {A Self-Orienting Single-Chip Ingestible Pill for Electrochemical Sensing in the GI Tract}, author = {Abdigazy, Angsagan and Islam, Mohammad Shafiqul and Arfan, Mohammed and Hassan, Md Farhad and Hashemi, Hossein and Khan, Yasser}, booktitle = {2024 IEEE Biomedical Circuits and Systems Conference (BioCAS)}, year = {2024}, organization = {IEEE}, url = {http://dx.doi.org/10.1109/BioCAS61083.2024.10798307}, doi = {10.1109/BioCAS61083.2024.10798307}, thumbnail = {abdigazy2024self.png}, pdf = {abdigazy2024self.pdf} }

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